tamagatchu:

alien girls in the club

tamagatchu:

alien girls in the club

16 minutes ago · 482 notes · Reblog
#cute art 
cutieteeth:

So much fruit!
high resolution →

cutieteeth:

So much fruit!

18 minutes ago · 189 notes · Reblog
#cute art 

annalaatikko:

Talk Finnish to me

*saatananmoinen kantelesoolo*

koochinko-art:

Hello followers!! Thank you so much for the positive feedback! This is an old doodle. ♥
high resolution →

koochinko-art:

Hello followers!! Thank you so much for the positive feedback! This is an old doodle. ♥

8 hours ago · 1,141 notes · Reblog
#cute art 

indikos:

burned my hand curling my hair today

worth it

8 hours ago · 71,221 notes · Reblog
#hair #ladies 

octobaba:

okay so I’ve had this “earworm” megane megan fox in my head for a month but i had no idea what megane means in japanese so today i checked it and now I can present you a megane megan fox

image

(Source: seafolklore)

15 hours ago · 1,337 notes · Reblog
#mermaid 
werpiper:

neurosciencestuff:

Researchers discover fever’s origin
Fever is a response to inflammation, and is triggered by an onset of the signaling substance prostaglandin. Researchers at Linköping University can now see precisely where these substances are produced – a discovery that paves the way for smarter drugs.
When you take an aspirin, all production of prostaglandins in the body is suppressed. All symptoms of inflammation are eased simultaneously, including fever, pain and loss of appetite. But it might not always be desirable to get rid of all symptoms – there is a reason why they appear.
”Perhaps you want to inhibit loss of appetite but retain fever. In the case of serious infections, fever can be a good thing,” says David Engblom, senior lecturer in neurobiology at Linköping University.
Eleven years ago he had his first breakthrough as a researcher when he uncovered the mechanism behind the formation of prostaglandin E2 during fever. These signaling molecules cannot pass the blood-brain barrier, the purpose of which is to protect the brain from hazardous substances. Engblom showed that instead, they could be synthesised from two enzymes in the blood vessels on the inside of the brain, before moving to the hypothalamus, where the body’s thermostat is located.
Previous work from the research team described a very simple mechanism, but there was not yet proof that it was important in real life. The study to be published in The Journal of Neuroscience with David Engblom and his doctoral student Daniel Wilhelms as lead authors is based on tests with mice that lack the enzymes COX-2 and mPGES-1 in the brain’s blood vessels. When they were infected with bacterial toxins the fever did not appear, while other signs of inflammation were not affected.
”This shows that those prostaglandins which cause fever are formed in the blood-brain barrier – nowhere else. Now it will be interesting to investigate the other inflammation symptoms. Knowledge of this type can be useful when developing drugs that ease certain symptoms, but not all of them,” explains David Engblom.
For many years there has been debate as to where the fever signaling originates. Three alternative ideas have been proposed. Firstly, that it comes from prostaglandins circulating in the blood, secondly that it comes from immune cells in the brain, and thirdly Engblom’s theory, which stresses the importance of the brain’s blood vessels. The third proposal can now be considered confirmed.

HOW ASPIRIN WORKS!

werpiper:

neurosciencestuff:

Researchers discover fever’s origin

Fever is a response to inflammation, and is triggered by an onset of the signaling substance prostaglandin. Researchers at Linköping University can now see precisely where these substances are produced – a discovery that paves the way for smarter drugs.

When you take an aspirin, all production of prostaglandins in the body is suppressed. All symptoms of inflammation are eased simultaneously, including fever, pain and loss of appetite. But it might not always be desirable to get rid of all symptoms – there is a reason why they appear.

”Perhaps you want to inhibit loss of appetite but retain fever. In the case of serious infections, fever can be a good thing,” says David Engblom, senior lecturer in neurobiology at Linköping University.

Eleven years ago he had his first breakthrough as a researcher when he uncovered the mechanism behind the formation of prostaglandin Eduring fever. These signaling molecules cannot pass the blood-brain barrier, the purpose of which is to protect the brain from hazardous substances. Engblom showed that instead, they could be synthesised from two enzymes in the blood vessels on the inside of the brain, before moving to the hypothalamus, where the body’s thermostat is located.

Previous work from the research team described a very simple mechanism, but there was not yet proof that it was important in real life. The study to be published in The Journal of Neuroscience with David Engblom and his doctoral student Daniel Wilhelms as lead authors is based on tests with mice that lack the enzymes COX-2 and mPGES-1 in the brain’s blood vessels. When they were infected with bacterial toxins the fever did not appear, while other signs of inflammation were not affected.

”This shows that those prostaglandins which cause fever are formed in the blood-brain barrier – nowhere else. Now it will be interesting to investigate the other inflammation symptoms. Knowledge of this type can be useful when developing drugs that ease certain symptoms, but not all of them,” explains David Engblom.

For many years there has been debate as to where the fever signaling originates. Three alternative ideas have been proposed. Firstly, that it comes from prostaglandins circulating in the blood, secondly that it comes from immune cells in the brain, and thirdly Engblom’s theory, which stresses the importance of the brain’s blood vessels. The third proposal can now be considered confirmed.

HOW ASPIRIN WORKS!

wildboysandwhiskey:

angelclark:

99-Year-Old Lady Sews A Dress A Day For Children In Need 

Lillian Weber, a 99-year-old good Samaritan from Iowa, has spent the last few years sewing a dress a day for the Little Dresses For Africa charity, a Christian organization that distributes dresses to children in need in Africa and elsewhere.

Weber’s goal is to make 1,000 dresses by the time she turns 100 on May 6th. So far, she’s made more than 840. Though she says she could make two a day, she only makes one – but each single dress she makes per day is personalized with careful stitchwork. She hopes that each little girl who receives her dress can take pride in her new garment.

This is so incredibly precious, this actually makes me tear up with happiness!

18 hours ago · 152,578 notes · Reblog
#info 

uuvuttaa:

adayinthelesbianlife:

Two Mothers, 2013
Portrait series by Aino Vuokola
Finland

These pictures are super lovely, but I’d like to give a small reminder to all Finns (and why not to all other people):

Gay marriage isn’t yet legal in Finland. Remember to send messages to your parliamentarians, so the one’s who oppose the law won’t get to put it down this Autumn. Thank you.

(Source: ainovuokola.com)

22 hours ago · 3,858 notes · Reblog
#photography 
braydaaan:


hes only seconds old and hes prepared for the world
live long and prosper little dude..

omggggg

braydaaan:

hes only seconds old and hes prepared for the world

live long and prosper little dude..

omggggg

(Source: togifs)

the-dark-mori-lolita:

lace-a-la-mode:

truth2teatold:

Quaint Lass Monet’s Garden Set

GORGEOUS

Follow me into the woods. A dark mori and lolita fashion blog.

high resolution →

(Source: starpatches)

23 hours ago · 1,457 notes · Reblog
#cute art 
aphcutie:


看板娘 by: REO*spikee


**permission to upload this was given by the artist**
high resolution →

aphcutie:

看板娘 by: REO*spikee

**permission to upload this was given by the artist**

1 day ago · 3,184 notes · Reblog
#cute art 

curvellas:

tumblr made me a much more tolerant and less judgmental person like my cousin be like “omg look at that bitch eyebrows she drew them damn near in her hairline” and i’m like shrug maybe the bitch wanted to have eyebrows in her hairline you don’t know shit about her life.

1 day ago · 419,243 notes · Reblog